Tradeshows and Events

June 1-5, 2020	Microscopy Society of Canada, Sherbrooke, Canada

 

News

Oct 2019	Lyncean Technologies awarded €49M to provide world’s most advanced gamma-ray source
May 2018	Lyncean Technologies Inc. closes $13.75 million funding with a syndicate including Intel Capital
August 2017	Lyncean Technologies Signs Edge Scientific as Representative in Canada
May 2017	TUM and Lyncean Technologies Announce a 3x Flux Increase from the Munich Compact Light Source
April 2017	Lyncean Technologies Signs Shanghai Physion as Representative in China
March 2017	Lyncean Technologies Signs AXT as Rep in Australia and New Zealand
December 2016	Lyncean Technologies Receives $650,000 in Series A Funding
August 2016	Customer publishes performance evaluation of first commercial mini-synchrotron
May 2016	Lyncean Technologies Inc. receives export achievement award at Hannover Messe, Germany
April 2016	New state-of-the-art compact X-ray source, World’s first mini particle accelerator for high-brilliance X-rays at TUM
March 2016	Fremont compact X-ray startup names ex-Zeiss executive as CEO
October 2015	World’s First Mini Synchrotron Inaugurated at Technical University of Munich
October 2015	World’s First Mini Particle Accelerator for High-Brilliance X-Rays at TUM
October 2015	Lyncean Technologies Brings X-Ray Focus to Export Market
August 2015	Lyncean Technologies Offers a Compact X-Ray Source for Researchers
May 2015	Compact Laser-Driven Synchrotron Shines X-Rays on Soft Tissue
May 2015	Innovative Compact Light Source Generates X-rays Suitable for Advanced Tomography
May 2015	First Miniature Synchrotron Now in Commercial Operation
May 2015	Compact Light Source Improves CT Scans
April 2015	Compact Synchrotron Makes Tumors Visible
April 2015	First Miniature Synchrotron Now in Commercial Operation
February 2015	Novel X-ray Technology Improves Contrast in Soft Tissue
March 2014	TSC Panelists Discuss Role of Research Funding in Moving Innovation from the Lab to the Marketplace (PDF Download)
March 2013	Lyncean Technologies, Inc. receives $1.1M grant from DOE to develop the Compact Light Source
December 2012	Lyncean Technologies Inc. sells Compact Light Source to Munich biomedical-imaging research center
October 2012	Scattered X-rays reveal diseased tissue: X-ray technology improves early detection of pulmonary disease
July 2012	Bay Area companies join ‘insourcing’ trend
January 2012	Crowd-sourcing the Future of Accelerators
May 2011	Lyncean Technologies raises $1M for X-rays
May 2009	Synchrotron source enhances soft-tissue imaging
May 2009	Lyncean Technologies Inc. receives $1.2 M from NCRR to develop new imaging technique
January 2009	First Science from the Compact Light Source: A miniature synchrotron for your home lab
January 2009	Hard X-ray Phase Contrast Imaging with the Compact Light Source
February 2008	A Miniature Synchrotron
June 2006	Miniature Synchrotron Sheds New Light on Research (PDF Download)
May 2006	Miniature Synchrotron Lights Up
May 2006	My Own Private Synchrotron
March 2006	Miniature Synchrotron Produces First Light
March 2005	Automating, Miniaturizing X-ray Crystallography
June 2004	Shrinking the Synchrotron
May 2004	Compact Light Sources
April 2004	Lasers Bend Beams for Desktop X-ray Source
April 2004	Get Your Own Desktop Synchrotron
April 2004	Crystallographers take note: A synchrotron light source for your home lab
February 2003	Compact Light Source Goes Commercial

Publications

Imaging Publications

L. Heck, E. Eggl, S. Grandl, M. Dierolf, C. Jud, B. Günther, K. Achterhold, D. Mayr, B. Gleich, K. Hellerhoff, F. Pfeiffer, and J. Herzen. Dose and spatial resolution analysis of grating-based phase-contrast mammography using an inverse Compton x-ray source. Journal of Medical Imaging 7(2), 023505 (2020) [doi 10.1117/1.JMI.7.2.023505]

S. Kulpe, M. Dierolf, E.-M. Braig, B. Günther, K. Achterhold, B. Gleich, J. Herzen, E. Rummeny, F. Pfeiffer, and D. Pfeiffer. K-edge subtraction imaging for iodine and calcium separation at a compact synchrotron x-ray source. Journal of Medical Imaging 7(2), 023504 (2020) [doi: 10.1117/1.JMI.7.2.023504]

L. Yang, R. Gradl, M. Dierolf, W. Möller, D. Kutschke, A. Feuchtinger, L. Hehn, M. Donnelley, B. Günther, K. Achterhold, A. Walch, T. Stoeger, D. Razansky, F. Pfeiffer, K.S. Morgan, and O. Schmid. Multimodal Precision Imaging of Pulmonary Nanoparticle Delivery in Mice: Dynamics of Application, Spatial Distribution, and Dosimetry. Small 1904112 (2019) [doi:10.1002/smll.201904112]

L. Heck, M. Dierolf, C. Jud, E. Eggl, T. Sellerer, K. Mechlem, B. Günther, K. Achterhold, B. Gleich, S. Metz, D. Pfeiffer, K. Kröninger, J. Herzen. Contrast-enhanced spectral mammography with a compact synchrotron source. PLoS ONE 14(10):e0222816 (2019) [doi:10.1371/journal.pone.0222816]

S. Kulpe, M. Dierolf, B. Günther, M. Busse, K. Achterhold, B. Gleich, J. Herzen, E. Rummeny, F. Pfeiffer, D. Pfeiffer. K-edge Subtraction Computed Tomography with a Compact Synchrotron X-ray Source. Scientific Reports 9:13332 (2019) [doi:10.1038/s41598-019-49899-z]

R. Gradl, M. Dierolf, L. Yang, L. Hehn, B. Günther, W. Möller, D. Kutschke, T. Stoeger, B. Gleich, K. Achterhold, M. Donnelley, F. Pfeiffer, O. Schmid, K.S. Morgan. Visualizing treatment delivery and deposition in mouse lungs using in vivo x-ray imaging. Journal of Controlled Release 307, 282-291 (2019) [doi:10.1016/j.jconrel.2019.06.035]

S. Kulpe, M. Dierolf, E. Braig, B. Günther, K. Achterhold, B. Gleich, J. Herzen, E. Rummeny, F. Pfeiffer, D. Pfeiffer. K-edge subtraction imaging for coronary angiography with a compact synchrotron X-ray source, PLoS ONE, 13(12):e0208446 (2018), [doi.org/10.1371/journal.pone.0208446]

E. Braig, J. Böhm, M. Dierolf, C. Jud, B. Günther, K. Mechlem, S. Allner, T. Sellerer, K. Achterhold, B. Gleich, P Noël, D. Pfeiffer, E. Rummeny, J. Herzen and F. Pfeiffer. Direct quantitative material decomposition employing grating-based X-ray phase-contrast CT. Scientific Reports 8:16394 (2018) [doi: 10.1038/s41598-018-34809-6]

E. Eggl, S. Grandl, A. Sztrókay-Gaul, M. Dierolf, C. Jud, L. Heck, K. Burger, B. Günther, K. Achterhold, D. Mayr, J.J. Wilkens, S.D. Auweter, B. Gleich, K. Hellerhoff, M.F. Reiser, F. Pfeiffer and J. Herzen. Dose-compatible grating-based phase-contrast mammography on mastectomy specimens using a compact synchrotron source. Scientific Reports 8:15700 (2018) [doi: 10.1038/s41598-018-33628-z]

R. Gradl, K.S. Morgan, M. Dierolf, C. Jud, L. Hehn, B. Günther, W. Möller, D. Kutschke, L. Yang, T. Stoeger, D. Pfeiffer, B. Gleich, K. Achterhold, O.Schmid, and F. Pfeiffer. Dynamic in vivo chest x-ray dark-field imaging in mice. IEEE Transaction on Medical Imaging 38(2), 649-656 (2019) [doi: 10.1109/TMI.2018.2868999]

R. Gradl, M. Dierolf, B. Günther, L. Hehn, W. Möller, D. Kutschke, L. Yang, M. Donnelley, R. Murrie, A. Erl, T. Stoeger, B. Gleich, K. Achterhold, O. Schmid, F. Pfeiffer & K. S. Morgan. In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source. Scientific Reports 8:6788 (2018) [doi:10.1038/s41598-018-24763-8]

M. Töpperwien, R. Gradl, D. Keppeler, M. Vassholz, A. Meyer, R. Hessler, K. Achterhold, B. Gleich, M. Dierolf, F. Pfeiffer, T. Moser & T. Salditt. Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source. Scientific Reports 8:4922 (2018) [doi:10.1038/s41598-018-23144-5]

C. Jud, E. Braig, M. Dierolf, E. Eggl, B. Günther, K. Achterhold, B. Gleich, E. Rummeny, P. Noël, F. Pfeiffer & D. Muenzel. Trabecular bone anisotropy imaging with a compact laser-undulator synchrotron x-ray source. Scientific Reports 7:14477 (2017) [doi:10.1038/s41598-017-14830-x]

R. Gradl, M. Dierolf, L. Hehn, B. Günter, A Ö. Yildirim, B. Gleich, K. Achterhold, F. Pfeiffer & K.S. Morgan. Propagation-based Phase-Contrast X-ray Imaging at a Compact Light Source. Scientific Reports 7:4908 (2017) [doi: 10.1038/s41598-017-04739-w]

E. Eggl, K. Mechlem, E. Braig, S. Kulpe, M. Dierolf, B. Günther, K. Achterhold, J. Herzen, B. Gleich, E. Rummeny, P. Noël, F. Pfeiffer, and D. Muenzel. Mono-Energy Coronary Angiography with a Compact Synchrotron Source. Scientific Reports 4:72211 (2017) [doi: 10.1038/srep42211]

E. Eggl, S. Schleede, M. Bech, K. Achterhold, S. Grandl, A. Sztrokay, K. Hellerholff, D. Mayr, R. Loewen, R. Ruth, M. Feser, and F. Pfeiffer. X-ray Phase-Contrast Tomosynthesis of a Human Ex Vivo Slice with an Inverse Compton X-ray Source. EPL 16, 68003  (2016) [doi.org/10.1209/0295-5075/116/68003]

E. Eggl, S. Schleede, M. Bech, K. Achterhold, R. Loewen, R. Ruth and F. Pfeiffer. X-ray phase-contrast tomography with a compact laser-driven synchrotron source. PNAS (2015) [doi: 10.1073/pnas.1500938112]

F. Schwab, S. Schleede, D. Hahn, M. Bech, J. Herzen, S. Auweter, F. Bamberg, K. Achterhold, A. Ö. Yildirim, A. Bohla, O. Eickelberg, R. Loewen, M. Gifford, R. Ruth, M. F. Reiser, K. Nikolaou, F. Pfeiffer and F. G. Meinel. Comparison of Contrast-to-Noise Ratios of Transmission and Dark-Field Signal in Grating-Based x-ray Imaging for Healthy Murine Lung Tissue. Zeitschrift für Medizinische Physik 23(3), 236-42 (2013) [doi:10.1016/j.zemedi.2012.11.003]

J. Fu, S. Schleede, R. Tan, L. Chen, M. Bech, K. Achterhold, M. Gifford, R. Loewen, R. Ruth, and F. Pfeiffer. An algebraic iterative reconstruction technique for differential X-ray phase-contrast computed tomography. Zeitschrift für Medizinische Physik 23(3), 186–193 (2013) [doi:10.1016/j.zemedi.2012.11.002]

F. G. Meinel, F. Schwab, S. Schleede, M. Bech, J. Herzen, K. Achterhold, S. Auweter, F. Bamberg, A. Ö. Yildirim, A. Bohla, O. Eickelberg, R. Loewen, M. Gifford, R. Ruth, M. F. Reiser, F. Pfeiffer and K. Nikolaou (2013). Diagnosing and Mapping Pulmonary Emphysema on X-Ray Projection Images: Incremental Value of Grating-Based X-Ray Dark-Field Imaging. PLoS ONE 8(3):e59526 (2013) [doi:10.1371/journal.pone.0059526]

K. Achterhold, M. Bech, S. Schleede, G. Potdevin, R. Ruth, R. Loewen and F. Pfeiffer. Monochromatic computed tomography with a compact laser-driven synchrotron X-ray source. Scientific Reports 3:1313 (2013) [doi:10.1038/srep01313]

S. Schleede, F.G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S.F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A.Ö. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser and F. Pfeiffer. Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source. PNAS (2012) [doi:10.1073/pnas.1206684109]

S. Schleede, M. Bech, K. Achterhold, G. Potdevin, M. Gifford, R. Loewen, C. Limborg, R. Ruth and F. Pfeiffer. Multimodal Hard X-ray Imaging of a Mammography Phantom at a Compact Synchrotron Light Source. Journal of Synchrotron Radiation 19, 525-529 (2012) [doi:10.1107/S0909049512017682]

M. Bech, S. Schleede, G. Potdevin, K. Achterhold, O. Bunk, T.H. Jensen, R. Loewen, R. Ruth and F. Pfeiffer. Experimental validation of image contrast correlation between ultra-small-angle X-ray scattering and grating-based dark-field imaging using a laser-driven compact X-ray source. Photonics & Lasers in Medicine 1, 47-50 (2012) [doi:10.1515/plm-2011-0012]

M. Bech, O. Bunk, C. David, R. Ruth, J. Rifkin, R. Loewen, R. Feidenhans’l and F. Pfeiffer. Hard X-ray phase-contrast imaging with the Compact Light Source based on inverse Compton X-rays. Journal of Synchrotron Radiation 16, 43-47 (2009) [doi:10.1107/S090904950803464X]

Protein Crystallography Publications

J. Abendroth, M.S. McCormick, T.E. Edwards, B. Staker and R. Loewen, M. Gifford, J. Rifkin, C. Mayer, W. Guo, Y. Zhang, P. Myler, A. Kelley, E. Analau, S.N. Hewitt, A. Napuli, P. Kuhn, R.D. Ruth and L.J. Stewart. X-ray Structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source. Journal of Structural and Functional Genomics 11(1), 91-100 (2010) [doi:10.1007/s10969-010-9087-6]

Micro-Beam Radiation Therapy

A.C. Dombrowsky, K. Burger, A. Porth, M. Stein, M. Dierolf, B. Günther, K. Achterhold, B. Gleich, A. Feuchtinger, S. Bartzsch, E. Beyreuther, S.E. Combs, F. Pfeiffer, J.J. Wilkens & T.E. Schmid. A proof of principle experiment for microbeam radiation therapy at the Munich compact light source. Radiation And Environmental Biophysics 59, 111-120 (2020)  [doi:10.1007/s00411-019-00816-y]

K. Burger, K. Ilicic, M. Dierolf, B. Günther, D.W.M. Walsh, E. Schmid, E. Eggl, K. Achterhold, B. Gleich, S. Combs, M. Molls, T. Schmid, F. Pfeiffer, J.J. Wilkens. Increased cell survival and cytogenetic integrity by spatial dose redistribution at a compact synchrotron X-ray source, PLoS One 10:1371 (2017) [doi:10:1371/journal.pone.0186005]

CLS (Inverse Compton Scattering) References

B. Hornberger, J. Kasahara, M. Gifford, R. Ruth, R. Loewen. A compact light source providing high-flux, quasi-monochromatic, tunable X-rays in the laboratory. Proceedings of SPIE 11110, Advances in Laboratory-based X-ray Sources, Optics, and Applications VII, 11111003 (2019) [doi.org/10.1117/12.2527356]

B. Günther, M. Dierolf, K. Achterhold, F. Pfeiffer. Device for source position stabilization and beam parameter monitoring at inverse Compton X-ray sources. Journal of Synchrotron Radiation 26, 1546-1553 (2019) [doi:10.1107/S1600577519006453]

B. Günther, M. Dierolf, R. Gradl, E. Eggl, C. Jud, L. Hehn, S. Kulpe, B. Gleich, M. Busse, K.S. Morgan, K. Achterhold, and F. Pfeiffer. The Munich Compact Light Source:  Biomedical Research at a Laboratory-Scale Inverse-Compton Synchrotron X-ray Source. Microscopy and Microanalysis 24:S1 (2018)   [doi.org/10.1017/S143192761800541X]

M. Feser, R. Ruth, R. Loewen, J. Kasahara. Bridging the Synchrotron – Lab Source Gap for Microscopy: The Inverse Compton Scattering X-ray Source. Microscopy and Microanalysis 24:S2 (2018) [doi:10.1017/S1431927618013879]

E. Eggl, M. Dierolf, K. Achterhold, C. Jud, B. Günther, E. Braig, B. Gleich and F. Pfeiffer. The Munich Compact Light Source: Initial performance measures. Journal of Synchrotron Radiation 23, 1137-1142 (2016) [doi:10.1107/s160057751600967X]

Roderick Loewen. A compact light source: design and technical feasibility study of a laser-electron storage ring x-ray source, Stanford University Physics Ph.D. Dissertation, SLAC-R-632 (2003)

Zhirong Huang, Ronald D. Ruth. Laser-electron storage ring. Physical Review Letters 80, 976-979 (1998) [doi:10.1103/PhysRevLett.80.976]