EventsNewsPublications Tradeshows and Events June 1-5, 2020 Microscopy Society of Canada, Sherbrooke, Canada News Oct 2019 Lyncean Technologies awarded €49M to provide world’s most advanced gamma-ray source May 2018 Lyncean Technologies Inc. closes $13.75 million funding with a syndicate including Intel Capital August 2017 Lyncean Technologies Signs Edge Scientific as Representative in Canada May 2017 TUM and Lyncean Technologies Announce a 3x Flux Increase from the Munich Compact Light Source April 2017 Lyncean Technologies Signs Shanghai Physion as Representative in China March 2017 Lyncean Technologies Signs AXT as Rep in Australia and New Zealand December 2016 Lyncean Technologies Receives $650,000 in Series A Funding August 2016 Customer publishes performance evaluation of first commercial mini-synchrotron May 2016 Lyncean Technologies Inc. receives export achievement award at Hannover Messe, Germany April 2016 New state-of-the-art compact X-ray source, World’s first mini particle accelerator for high-brilliance X-rays at TUM March 2016 Fremont compact X-ray startup names ex-Zeiss executive as CEO October 2015 World’s First Mini Synchrotron Inaugurated at Technical University of Munich October 2015 World’s First Mini Particle Accelerator for High-Brilliance X-Rays at TUM October 2015 Lyncean Technologies Brings X-Ray Focus to Export Market August 2015 Lyncean Technologies Offers a Compact X-Ray Source for Researchers May 2015 Compact Laser-Driven Synchrotron Shines X-Rays on Soft Tissue May 2015 Innovative Compact Light Source Generates X-rays Suitable for Advanced Tomography May 2015 First Miniature Synchrotron Now in Commercial Operation May 2015 Compact Light Source Improves CT Scans April 2015 Compact Synchrotron Makes Tumors Visible April 2015 First Miniature Synchrotron Now in Commercial Operation February 2015 Novel X-ray Technology Improves Contrast in Soft Tissue March 2014 TSC Panelists Discuss Role of Research Funding in Moving Innovation from the Lab to the Marketplace (PDF Download) March 2013 Lyncean Technologies, Inc. receives $1.1M grant from DOE to develop the Compact Light Source December 2012 Lyncean Technologies Inc. sells Compact Light Source to Munich biomedical-imaging research center October 2012 Scattered X-rays reveal diseased tissue: X-ray technology improves early detection of pulmonary disease July 2012 Bay Area companies join ‘insourcing’ trend January 2012 Crowd-sourcing the Future of Accelerators May 2011 Lyncean Technologies raises $1M for X-rays May 2009 Synchrotron source enhances soft-tissue imaging May 2009 Lyncean Technologies Inc. receives $1.2 M from NCRR to develop new imaging technique January 2009 First Science from the Compact Light Source: A miniature synchrotron for your home lab January 2009 Hard X-ray Phase Contrast Imaging with the Compact Light Source February 2008 A Miniature Synchrotron June 2006 Miniature Synchrotron Sheds New Light on Research (PDF Download) May 2006 Miniature Synchrotron Lights Up May 2006 My Own Private Synchrotron March 2006 Miniature Synchrotron Produces First Light March 2005 Automating, Miniaturizing X-ray Crystallography June 2004 Shrinking the Synchrotron May 2004 Compact Light Sources April 2004 Lasers Bend Beams for Desktop X-ray Source April 2004 Get Your Own Desktop Synchrotron April 2004 Crystallographers take note: A synchrotron light source for your home lab February 2003 Compact Light Source Goes Commercial Publications Imaging Publications S. Kulpe, M. Dierolf, B. Günther, J. Brantl, M. Busse, K. Achterhold, B. Gleich, F. Pfeiffer, D. PfeifferDynamic K-edge Subtraction Fluoroscopy at a Compact Inverse-Compton Synchrotron X-ray Source Scientific Reports 10:9612 (2020) [doi:10.1038/s41598-020-66414-x] B. Günther, R. Gradl, C. Jud, E. Eggl, S. Kulpe, E. Braig, L. Heck, J. Brantl, K. Achterhold, B. Gleich, M. Dierolf, F. PfeifferEvaluation and optimization of multimodal x-ray imaging techniques for inverse Compton x-ray sources Proc. SPIE 11110, Advances in Laboratory-based X-Ray Sources, Optics, and Applications VII 1111008 (2019) [doi:10.1117/12.2529667] S. Kulpe, M. Dierolf, E. Braig, B. Günther, K. Achterhold, B. Gleich, J. Herzen, E. Rummeny, F. Pfeiffer, D. PfeifferK-edge subtraction imaging for angiography at a compact synchrotron sourceProc. SPIE 11110, Advances in Laboratory-based X-Ray Sources, Optics, and Applications VII 111100J (2019) [doi:10.1117/12.2526771] K.S. Morgan, R. Gradl, M. Dierolf, C. Jud, B. Günther, F. Werdiger, M. Gardner, P. Cmielewski, A. McCarron, N. Farrow, H. Haas, M.A. Kimm, L. Yang, D. Kutschke, T. Stoeger, O. Schmid, K. Achterhold, F. Pfeiffer, D. Parsons, M. DonnelleyIn vivo x-ray imaging of the respiratory system using synchrotron sources and a compact light source Proc. SPIE 11113, Developments in X-Ray Tomography XII 111130G (2019) [doi:10.1117/12.2529276] E. Braig, M. Dierolf, B. Guenther, K. Mechlem, S. Allner, T. Sellerer, K. Achterhold, B. Gleich, E. Rummeny, D. Pfeiffer, F. Pfeiffer, J. Herzen Single-energy material decomposition with grating-based x-ray phase-contrast CTProc. SPIE 11113, Developments in X-Ray Tomography XII 111130R (2019) [doi:10.1117/12.2528384] L. Heck, E. Eggl, S. Grandl, M. Dierolf, C. Jud, B. Günther, K. Achterhold, D. Mayr, B. Gleich, K. Hellerhoff, F. Pfeiffer, J. HerzenDose and spatial resolution analysis of grating-based phase-contrast mammography using an inverse Compton x-ray source Proc. SPIE 11113, Developments in X-Ray Tomography XII 111130M (2019) [doi:10.1117/12.2527981] L. Heck, E. Eggl, S. Grandl, M. Dierolf, C. Jud, B. Günther, K. Achterhold, D. Mayr, B. Gleich, K. Hellerhoff, F. Pfeiffer, and J. HerzenDose and spatial resolution analysis of grating-based phase-contrast mammography using an inverse Compton x-ray source Journal of Medical Imaging 7(2), 023505 (2020) [doi 10.1117/1.JMI.7.2.023505] S. Kulpe, M. Dierolf, E.-M. Braig, B. Günther, K. Achterhold, B. Gleich, J. Herzen, E. Rummeny, F. Pfeiffer, and D. PfeifferK-edge subtraction imaging for iodine and calcium separation at a compact synchrotron x-ray source Journal of Medical Imaging 7(2), 023504 (2020) [doi:10.1117/1.JMI.7.2.023504] L. Yang, R. Gradl, M. Dierolf, W. Möller, D. Kutschke, A. Feuchtinger, L. Hehn, M. Donnelley, B. Günther, K. Achterhold, A. Walch, T. Stoeger, D. Razansky, F. Pfeiffer, K.S. Morgan, and O. SchmidMultimodal Precision Imaging of Pulmonary Nanoparticle Delivery in Mice: Dynamics of Application, Spatial Distribution, and DosimetrySmall 1904112 (2019) [doi:10.1002/smll.201904112] L. Heck, M. Dierolf, C. Jud, E. Eggl, T. Sellerer, K. Mechlem, B. Günther, K. Achterhold, B. Gleich, S. Metz, D. Pfeiffer, K. Kröninger, J. HerzenContrast-enhanced spectral mammography with a compact synchrotron source PLoS ONE 14(10):e0222816 (2019) [doi:10.1371/journal.pone.0222816] S. Kulpe, M. Dierolf, B. Günther, M. Busse, K. Achterhold, B. Gleich, J. Herzen, E. Rummeny, F. Pfeiffer, D. PfeifferK-edge Subtraction Computed Tomography with a Compact Synchrotron X-ray Source.Scientific Reports 9:13332(2019) [doi:10.1038/s41598-019-49899-z] R. Gradl, M. Dierolf, L. Yang, L. Hehn, B. Günther, W. Möller, D. Kutschke, T. Stoeger, B. Gleich, K. Achterhold, M. Donnelley, F. Pfeiffer, O. Schmid, K.S. MorganVisualizing treatment delivery and deposition in mouse lungs using in vivo x-ray imagingJournal of Controlled Release 307, 282-291 (2019) [doi:10.1016/j.jconrel.2019.06.035] S. Kulpe, M. Dierolf, E. Braig, B. Günther, K. Achterhold, B. Gleich, J. Herzen, E. Rummeny, F. Pfeiffer, D. PfeifferK-edge subtraction imaging for coronary angiography with a compact synchrotron X-ray source PLoS ONE 13(12):e0208446 (2018), [doi.org/10.1371/journal.pone.0208446] E. Braig, J. Böhm, M. Dierolf, C. Jud, B. Günther, K. Mechlem, S. Allner, T. Sellerer, K. Achterhold, B. Gleich, P Noël, D. Pfeiffer, E. Rummeny, J. Herzen and F. PfeifferDirect quantitative material decomposition employing grating-based X-ray phase-contrast CT Scientific Reports 8:16394 (2018) [doi:10.1038/s41598-018-34809-6] E. Eggl, S. Grandl, A. Sztrókay-Gaul, M. Dierolf, C. Jud, L. Heck, K. Burger, B. Günther, K. Achterhold, D. Mayr, J.J. Wilkens, S.D. Auweter, B. Gleich, K. Hellerhoff, M.F. Reiser, F. Pfeiffer and J. HerzenDose-compatible grating-based phase-contrast mammography on mastectomy specimens using a compact synchrotron sourceScientific Reports 8:15700 (2018) [doi:10.1038/s41598-018-33628-z] R. Gradl, K.S. Morgan, M. Dierolf, C. Jud, L. Hehn, B. Günther, W. Möller, D. Kutschke, L. Yang, T. Stoeger, D. Pfeiffer, B. Gleich, K. Achterhold, O.Schmid, and F. PfeifferDynamic in vivo chest x-ray dark-field imaging in miceIEEE Transaction on Medical Imaging 38(2), 649-656(2019) [doi:10.1109/TMI.2018.2868999] R. Gradl, M. Dierolf, B. Günther, L. Hehn, W. Möller, D. Kutschke, L. Yang, M. Donnelley, R. Murrie, A. Erl, T. Stoeger, B. Gleich, K. Achterhold, O. Schmid, F. Pfeiffer & K. S. MorganIn vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light SourceScientific Reports 8:6788 (2018) [doi:10.1038/s41598-018-24763-8] M. Töpperwien, R. Gradl, D. Keppeler, M. Vassholz, A. Meyer, R. Hessler, K. Achterhold, B. Gleich, M. Dierolf, F. Pfeiffer, T. Moser & T. SaldittPropagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron sourceScientific Reports 8:4922 (2018) [doi:10.1038/s41598-018-23144-5] C. Jud, E. Braig, M. Dierolf, E. Eggl, B. Günther, K. Achterhold, B. Gleich, E. Rummeny, P. Noël, F. Pfeiffer & D. MuenzelTrabecular bone anisotropy imaging with a compact laser-undulator synchrotron x-ray sourceScientific Reports 7:14477 (2017) [doi:10.1038/s41598-017-14830-x] R. Gradl, M. Dierolf, L. Hehn, B. Günter, A Ö. Yildirim, B. Gleich, K. Achterhold, F. Pfeiffer & K.S. MorganPropagation-based Phase-Contrast X-ray Imaging at a Compact Light SourceScientific Reports 7:4908 (2017) [doi:10.1038/s41598-017-04739-w] E. Eggl, K. Mechlem, E. Braig, S. Kulpe, M. Dierolf, B. Günther, K. Achterhold, J. Herzen, B. Gleich, E. Rummeny, P. Noël, F. Pfeiffer, and D. MuenzelMono-Energy Coronary Angiography with a Compact Synchrotron SourceScientific Reports 4:72211 (2017) [doi:10.1038/srep42211] E. Eggl, S. Schleede, M. Bech, K. Achterhold, S. Grandl, A. Sztrokay, K. Hellerholff, D. Mayr, R. Loewen, R. Ruth, M. Feser, and F. PfeifferX-ray Phase-Contrast Tomosynthesis of a Human Ex Vivo Slice with an Inverse Compton X-ray SourceEPL 16, 68003 (2016) [doi.org/10.1209/0295-5075/116/68003] E. Eggl, S. Schleede, M. Bech, K. Achterhold, R. Loewen, R. Ruth and F. PfeifferX-ray phase-contrast tomography with a compact laser-driven synchrotron sourcePNAS (2015) [doi:10.1073/pnas.1500938112] F. Schwab, S. Schleede, D. Hahn, M. Bech, J. Herzen, S. Auweter, F. Bamberg, K. Achterhold, A. Ö. Yildirim, A. Bohla, O. Eickelberg, R. Loewen, M. Gifford, R. Ruth, M. F. Reiser, K. Nikolaou, F. Pfeiffer and F. G. MeinelComparison of Contrast-to-Noise Ratios of Transmission and Dark-Field Signal in Grating-Based X-ray Imaging for Healthy Murine Lung TissueZeitschrift für Medizinische Physik 23(3), 236-42 (2013) [doi:10.1016/j.zemedi.2012.11.003] J. Fu, S. Schleede, R. Tan, L. Chen, M. Bech, K. Achterhold, M. Gifford, R. Loewen, R. Ruth, and F. PfeifferAn algebraic iterative reconstruction technique for differential X-ray phase-contrast computed tomographyZeitschrift für Medizinische Physik 23(3), 186–193 (2013) [doi:10.1016/j.zemedi.2012.11.002] F. G. Meinel, F. Schwab, S. Schleede, M. Bech, J. Herzen, K. Achterhold, S. Auweter, F. Bamberg, A. Ö. Yildirim, A. Bohla, O. Eickelberg, R. Loewen, M. Gifford, R. Ruth, M. F. Reiser, F. Pfeiffer and K. Nikolaou (2013)Diagnosing and Mapping Pulmonary Emphysema on X-Ray Projection Images: Incremental Value of Grating-Based X-Ray Dark-Field ImagingPLoS ONE 8(3):e59526 (2013)[doi:10.1371/journal.pone.0059526] K. Achterhold, M. Bech, S. Schleede, G. Potdevin, R. Ruth, R. Loewen and F. PfeifferMonochromatic computed tomography with a compact laser-driven synchrotron X-ray sourceScientific Reports 3:1313 (2013) [doi:10.1038/srep01313] S. Schleede, F.G. Meinel, M. Bech, J. Herzen, K. Achterhold, G. Potdevin, A. Malecki, S. Adam-Neumair, S.F. Thieme, F. Bamberg, K. Nikolaou, A. Bohla, A.Ö. Yildirim, R. Loewen, M. Gifford, R. Ruth, O. Eickelberg, M. Reiser and F. PfeifferEmphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light sourcePNAS (2012) [doi:10.1073/pnas.1206684109] S. Schleede, M. Bech, K. Achterhold, G. Potdevin, M. Gifford, R. Loewen, C. Limborg, R. Ruth and F. PfeifferMultimodal hard X-ray imaging of a mammography phantom at a compact synchrotron light sourceJournal of Synchrotron Radiation 19, 525-529 (2012) [doi:10.1107/S0909049512017682] M. Bech, S. Schleede, G. Potdevin, K. Achterhold, O. Bunk, T.H. Jensen, R. Loewen, R. Ruth and F. PfeifferExperimental validation of image contrast correlation between ultra-small-angle X-ray scattering and grating-based dark-field imaging using a laser-driven compact X-ray sourcePhotonics & Lasers in Medicine 1, 47-50 (2012) [doi:10.1515/plm-2011-0012] M. Bech, O. Bunk, C. David, R. Ruth, J. Rifkin, R. Loewen, R. Feidenhans’l and F. PfeifferHard X-ray phase-contrast imaging with the Compact Light Source based on inverse Compton X-raysJournal of Synchrotron Radiation 16, 43-47 (2009) [doi:10.1107/S090904950803464X] Spectroscopy Publications J. Huang, B. Günther, K. Achterhold, Y. Cui, B. Gleich, M. Dierolf, F. PfeifferEnergy-Dispersive X-ray Absorption Spectroscopy with an Inverse Compton SourceScientific Reports 10:8772 (2020) [doi:10.1038/s41598-020-65225-4] Protein Crystallography Publications J. Abendroth, M.S. McCormick, T.E. Edwards, B. Staker and R. Loewen, M. Gifford, J. Rifkin, C. Mayer, W. Guo, Y. Zhang, P. Myler, A. Kelley, E. Analau, S.N. Hewitt, A. Napuli, P. Kuhn, R.D. Ruth and L.J. StewartX-ray Structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray sourceJournal of Structural and Functional Genomics 11(1), 91-100 (2010) [doi:10.1007/s10969-010-9087-6] Micro-Beam Radiation Therapy Karin Burger, Theresa Urban, Annique C. Dombrowsky, Martin Dierolf, Benedikt Günther, Stefan Bartzsch, Klaus Achterhold, Stephanie E. Combs, Thomas E. Schmid, Jan J. Wilkens, and Franz PfeifferTechnical and dosimetric realization of in-vivo X-ray microbeam irradiations at the Munich Compact Light SourceMedical Physics, in press (2020) [doi:10.1002/mp.14433] A.C. Dombrowsky, K. Burger, A. Porth, M. Stein, M. Dierolf, B. Günther, K. Achterhold, B. Gleich, A. Feuchtinger, S. Bartzsch, E. Beyreuther, S.E. Combs, F. Pfeiffer, J.J. Wilkens & T.E. SchmidA proof of principle experiment for microbeam radiation therapy at the Munich compact light sourceRadiation And Environmental Biophysics 59, 111-120 (2020) [doi:10.1007/s00411-019-00816-y] K. Burger, K. Ilicic, M. Dierolf, B. Günther, D.W.M. Walsh, E. Schmid, E. Eggl, K. Achterhold, B. Gleich, S. Combs, M. Molls, T. Schmid, F. Pfeiffer, J.J. WilkensIncreased cell survival and cytogenetic integrity by spatial dose redistribution at a compact synchrotron X-ray sourcePLoS One 10:1371 (2017) [doi:10:1371/journal.pone.0186005] CLS (Inverse Compton Scattering) References B. Günther, R. Gradl, C. Jud, E. Eggl, J. Huang, S. Kulpe, K. Achterhold, B. Gleich, M. Dierolf and F. Pfeiffer The versatile X-ray beamline of the Munich Compact Light Source: design, instrumentation and applicationsJournal of Synchrotron Radiation 27 (2020) [doi.org10.1107/S1600577520008309] B. Hornberger, J. Kasahara, M. Gifford, R. Ruth, R. LoewenA compact light source providing high-flux, quasi-monochromatic, tunable X-rays in the laboratoryProceedings of SPIE 11110, Advances in Laboratory-based X-ray Sources, Optics, and Applications VII, 11111003 (2019) [doi.org/10.1117/12.2527356] B. Günther, M. Dierolf, K. Achterhold, F. PfeifferDevice for source position stabilization and beam parameter monitoring at inverse Compton X-ray sourcesJournal of Synchrotron Radiation 26, 1546-1553 (2019) [doi:10.1107/S1600577519006453] B. Günther, M. Dierolf, R. Gradl, E. Eggl, C. Jud, L. Hehn, S. Kulpe, B. Gleich, M. Busse, K.S. Morgan, K. Achterhold, and F. PfeifferThe Munich Compact Light Source: Biomedical Research at a Laboratory-Scale Inverse-Compton Synchrotron X-ray SourceMicroscopy and Microanalysis 24:S1 (2018) [doi.org/10.1017/S143192761800541X] M. Feser, R. Ruth, R. Loewen, J. KasaharaBridging the Synchrotron – Lab Source Gap for Microscopy: The Inverse Compton Scattering X-ray SourceMicroscopy and Microanalysis 24:S2 (2018) [doi:10.1017/S1431927618013879] E. Eggl, M. Dierolf, K. Achterhold, C. Jud, B. Günther, E. Braig, B. Gleich and F. PfeifferThe Munich Compact Light Source: Initial performance measuresJournal of Synchrotron Radiation 23, 1137-1142 (2016) [doi:10.1107/s160057751600967X] Roderick LoewenA compact light source: design and technical feasibility study of a laser-electron storage ring x-ray sourceStanford University Physics Ph.D. Dissertation, SLAC-R-632 (2003) Zhirong Huang, Ronald D. RuthLaser-electron storage ringPhysical Review Letters 80, 976-979 (1998) [doi:10.1103/PhysRevLett.80.976]
